Remus and Eisenmann may still offer a 500E-specific muffler. RENNtech does not. No aftermarket muffler will provide a power gain. Same for adding a Y-pipe in place of the middle muffler, that will shed ~15 lbs and sound nice, but it doesn't make any power. Ditto for the cats. The stock exhaust is oversized for the 5.0L engine. Aftermarket 500E mufflers are for looks and sound, not power.
There is basically nothing you can do for a 'tune' on these older engine management systems. If you buy a 1992 model, there really is nothing available, period. If you buy a 1993-94 model, you can install a 1992 LH (engine computer) module and this will give you approx 10hp gain at full throttle. That's it.
There is very, very little you can do to get more power from the 500E/E500 without installing NOS, forced induction, or a 6.0L engine. You can however make chassis modifications such as larger brakes (Silver Arrow setup), larger front sway bar (RENNtech, $600), wider wheels/tires, etc.