There has been somewhat conflicting information for years about biodegradable wiring harnesses and ETAs and such. And this also varies by platform (W124, R129, W140, etc.).
Basically the biodegradable wiring began being produced and was phased in on the production lines as it went into the supply chain. I believe we have had a fair number of 1992 owners who have had bad upper wiring harnesses and ETA internal and external cable wiring, as well as 1993 and 1994 E500E owners. There is no "set" month or date as to when the stuff is definitively good or bad.
I do believe that MOST ALL E500Es produced (likely from mid-1991 to mid-1995 series production) were made with the bad (biodegradable) wiring. Others may contest this, but again, we do not know the definitive date when any changeover would have been made from supposedly "good" to "bad" wiring in the harnesses. MB couldn't even tell you that.
I have seen reported in some places that 1992 owners didn't have any problems with wiring harnesses, and it was only a "model year" 1993, 1994 and 1995 thing on the W124 chassis. I don't believe this is true. There are a number of factors involved in the longevity of wiring harnesses and ETA cables - engine heat, number of heat cycles, whether the harness/cable has been disturbed (and if so how many times), and so forth.
Even non-biodegradable wiring insulation and harnesses can get brittle just from age/mileage/heat cycles. My 1989 560SEC has some visibly bad harnesses and wiring (where insulation has come off) from age and milage, and it was not even the biodegradable stuff! It's inevitable that the wiring will go bad at some point.
The good thing is that on the vast majority of cars, the harnesses have been replaced by this point in time, and it is very easy to determine whether a given car's
upper wiring harness or ETA is the original, or has been replaced.
It is an excellent idea, if one's harness has not been replaced, to proactively replace it. I did this back in 2004 or 2005 with my 1994 E500, with the upper harness, with only around 75K miles on the odometer. And I refurbished all of the internal and external wiring on my ETA in 2020, although it was badly failing, it had not caused any specific issues because it hadn't been disturbed. I had checked it also back in the 2005 time frame visually (slitting open the cable housing about an inch to look at the wire insulation) and at that time it was OK.
My
lower wiring harness I also replaced in 2020, as it was also in pretty bad condition though not actively failing. I had the replacement lower harness stored in my parts stock for nearly 10 years.